CODS - Journal of Dentistry

Register      Login

VOLUME 5 , ISSUE 1 ( March, 2013 ) > List of Articles

RESEARCH ARTICLE

Granular Cell Ameloblastoma - A Case Report

Mandana Donoghue, M Selvamani, Rajeshwari G. Annigeri, G.S Madhushankari, A. Yamuna Dev, Rajay A.D. Kamath

Citation Information : Donoghue M, Selvamani M, Annigeri RG, Madhushankari G, Dev AY, Kamath RA. Granular Cell Ameloblastoma - A Case Report. CODS J Dent 2013; 5 (1):1-4.

DOI: 10.5005/cods-5-1-1

License: CC BY-NC-ND 3.0

Published Online: 01-06-2013

Copyright Statement:  Copyright © 2013; The Author(s).


Abstract

Granular cell ameloblastoma is a rare variant, accounting for 1-5% (3.5%) of ameloblastomas. It has clinical behavior similar to other subtypes, and show high tendency to recur on conservative surgical approaches. It can also show metastasis, hence the treatment plan should include regular follow up of the patients, after radical surgery. Here we are presenting a case report of granular cell ameloblastoma occurring in a 45 years old male patient clinically, the lesion was occurring in the left posterior mandible creating soap bubble appearance on radiography. Histopathologically, granular cell changes were prominent. The granular appearance is due to lysosomal aggregation and their presence indicates degenerative change or related to aging phenomenon rather than aggressiveness. The lesion was treated by surgical resection and a period of 3 years follow up showed no recurrence.


PDF Share
  1. Cysts and tumors of odontogenic origin. In: Rajendran R, Sivapathasundharam B, editors. Shafer's textbook of Oral Pathology. 5th ed. Amsterdam: Elsevier Health Sciences; 2006. p. 381-91
  2. Odontogenic cysts and tumours. In: Neville BW, Damm DD, Allen CM, Bouquot JE, editors. Oral and Maxillofacial Pathology. 3rd ed. St. Louis: Saunders; 2009. p. 611-19.
  3. Cystic granular cell ameloblastoma. J Maxillofac Oral Surg 2010;9(3):310-3.
  4. Ameloblastoma: biological profile of 3677 cases. Eur J Cancer B Oral Oncol 1995;31B(2):86-99.
  5. Granular cell ameloblastoma with metastasis to the lung: Report of a case and review of the literature. Cancer 1965;18:916-25.
  6. The histogenesis and morphology of adamantinomas and other jaw tumors. Beitr Pathol Anat 1918;64:165-97.
  7. Ultrastructure of Granular Cell Ameloblastoma. Cancer 1971;27(4):948-55.
  8. Clinical pathology: Odontogenic and nonodontogenic tumors of the jaws. In: Maxillofacial Surgery. Booth PW, Schendel S, Hausamen JE, editors. 2nd ed. Vol 2. Churchill Livingstone; 2006
  9. Effectiveness of a new decisional algorithm in managing mandibular ameloblastomas: A 10-years experience. Br J Oral Maxillofac Surg 2007;45:306-10.
  10. Granular cell ameloblastoma -A case report. OMPJ 2011;2(2): 170-3.
  11. Granular cell ameloblastoma: A case report. Int J Oral Maxillofac Pathol 2011;2(4):63-7.
PDF Share
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.