Aims and background: Pemphigus is one of the autoimmune disorders that can be fatal and cause blisters, involving skin and mucous membranes. Autoantibodies are directed against the desmosomal intercellular adhesion molecules, leading to the loss of keratinocyte cell-to-cell adhesion. The oral lesion is the initial manifestation of pemphigus. Early recognition and management of oral pemphigus can prevent devastating skin involvement and reduce morbidity and mortality associated with it. Histopathology plays a vital role in confirming the diagnosis of pemphigus and differentiating it from other blistering disorders. This paper highlights the importance of pharmacological management, and investigations of oral pemphigus are discussed. Case description: A male patient in his 50s came to our outpatient department with the chief complaint of a painful ulcer in his oral cavity for the past 1 year. The patient presented with pain that aggravated on intake of hot and spicy food, with no relieving factors. On examination, the patient presented with multiple diffuse ulcers on the upper and lower labial mucosa, both sides of the buccal mucosa, as well as the ventral and dorsal surfaces of the tongue, with erythematous areas surrounding the lesions. Based on history and clinical examination, we arrived at a provisional diagnosis of oral pemphigus vulgaris (PV). A punch biopsy was performed. Histopathology and direct immunofluorescence reports revealed the diagnosis of PV. The patient was treated with systemic corticosteroids. The patient was followed up for 1 month and showed a remarkable recovery. Conclusion: PV is a chronic illness characterized by periods of recurrence and remission. It can be life-threatening, as it leads to the widespread loss of the skin's protective layer, potentially causing dehydration, malnutrition, and secondary infections. Early diagnosis and timely treatment are essential to improving patients’ quality of life.