Evaluation of Garlic Extract Gel as Local Drug Delivery in the Treatment of Chronic Periodontitis: A Clinical Study
Ravi T Reddy, Vandana KVP Kumar, Shobha Prakash
Keywords :
Clinical attachment level, Garlic, Herbal, Local drug delivery, Periodontitis, Probing depth, Scaling and root planing
Citation Information :
Reddy RT, Kumar VK, Prakash S. Evaluation of Garlic Extract Gel as Local Drug Delivery in the Treatment of Chronic Periodontitis: A Clinical Study. CODS J Dent 2018; 10 (1):1-6.
Objective: Here an attempt is made to assess the clinical benefits of garlic extract gel when used as an adjunct to nonsurgical periodontal therapy. Materials and methods: A total of 13 patients with periodontitis (AAP criteria) were selected. A split mouth design was used and sites in each patient were allocated into the experimental group and the control group. In the experimental group, sites were treated with scaling and root planing (SRP) + garlic gel. In the control group, sites were treated with SRP alone. Plaque index (PI), gingival bleeding index (GBI), gingival index (GI), probing pocket depth (PPD), and clinical attachment level (CAL) were assessed at baseline on 21st day, 30th day, and 90th day. Results: On intragroup comparison, the reduction in clinical parameters like PI, GI, GBI, and PPD was highly significant in both test and control groups (p ≤ 0.001), whereas CAL showed no significant gain in the control group but highly statistical significant result was seen in the test group. On intergroup comparison, all the clinical parameters like PI and CAL showed statistically significant (p ≤ 0.05) improvement the in test group when compared with that of the control group, whereas GI, GBI, and PPD showed statistically high significant (p ≤ 0.001) improvement in subjects with SRP + garlic gel when compared with SRP alone. Conclusion: These results conclude that garlic gel can be a used as an antibacterial and anti-inflammatory agent in adjunct to SRP. However, further research with larger samples needs to be focused to confirm the use of garlic in clinical practice.
Reddy PD, Satyanarayana T, Purushothaman M. Local drug delivery of herbs for treatment of periodontitis. J Inno Tren Pharm Sci 2010;1:245–251.
Kornman KS. Controlled release local delivery-antimicrobials in periodontics. Prospects for the future. J Periodontol 1993;64(8 Suppl): 782–791. DOI: 10.1902/jop.1993.64.8s.782.
Genco RJ. Host responses in periodontal diseases: current concepts. J Periodontol. 1992 Apr;63(4 Suppl):338–355.
Perinetti G, Paolantonio M, Cordella C, et al. Clinical and microbiological effects of subgingival administration of two active gels on persistent pockets of chronic periodontitis patients. J Clin Periodontol 2004;31(4):273–281. DOI: 10.1111/j.1600-051x.2004.00481.x.
Paolantonio M, D'Angelo M, Grassi RF, et al. Clinical and microbiologic effects of subgingival controlled-release delivery of chlorhexidine chip in the treatment of periodontitis: a multicenter study. J Periodontol 2008;79(2):271–282. DOI: 10.1902/jop.2008.070308.
Pistorius A, Willershausen B, Steinmeier EM, et al. Efficacy of subgingival irrigation using herbal extracts on gingival inflammation. J Periodontol 2003;74(5):616–622. DOI: 10.1902/jop.2003.74.5.616.
Chitme HR, Chandra R, Kaushik S. Studies on anti-diarrhoeal activity of calotropis gigantea in experimental animals. J Pharm Pharm Sci 2003;7(1):70–75.
Dhinahar S, Lakshmi T. Role of botanicals as antimicrobial agents in management of dental infections—a review. Int J Phar Biosci 2011;2(4):B690–B704.
Block E. The chemistry of garlic and onions. Sci Am 1985;252(3): 114–119. DOI: 10.1038/scientificamerican0385-114.
Armitage GC. Development of a classification system for periodontal diseases and conditions. Ann Periodontol 1999;4(1):1–6. DOI: 10.1902/annals.1999.4.1.1.
Antcziik-Bouckoms AA, Tulloch JFC, Berkey CS. Split-mouth and cross-over designs in dental research. J Clin Periodontol 1990; 17(7 Pt 1):446–453.
Stambaugh RV, Dragoo M, Smith DM, et al. The limits of subgingival Scaling. Int J Periodontics Restorative Dent 1981;1(5):30–41.
Lindhe J, Heijl L, Goodson JM, et al. Local tetracycline delivery using hollow fiber devices in periodontal therapy. J Clin Periodontol 1979;6(3):141–149. DOI: 10.1111/j.1600-051X.1979.tb02193.x.
Pavia M, Nobile CG, Angelillo IF. Meta-analysis of local tetracycline in treating chronic periodontitis. J Periodontol 2003 Jun;74(6):916–932. DOI: 10.1902/jop.2003.74.6.916.
Fani MM, Kohanteb J, Dayaghi M. Inhibitory activity of garlic (Allium sativum) extract on multidrug-resistant Streptococcus mutans. J Indian Soc Pedodont Prev Dent 2007;25(4):164–168. DOI: 10.4103/0970-4388.37011.
Lang A, Lahav M, Sakhnini E, et al. Allicin inhibits spontaneous and TNF-α induced secretion of proinflammatory cytokines and chemokines from intestinal epithelial cells. Clin Nutr 2004;23(5): 1199–1208. DOI: 10.1016/j.clnu.2004.03.011.
Mayne ST. Antioxidant nutrients and chronic disease: use of biomarkers of exposure and oxidative stress status in epidemiologic research. J Nutr 2003;133(3):933–940. DOI: 10.1093/jn/133. 3.933S.
Vazquez-Prieto MA, Gonzalez RE, Renna NF, et al. Aqueous garlic extracts prevent oxidative stress and vascular remodeling in an experimental model of metabolic syndrome. J Agric Food Chem 2010;58(11):630–635. DOI: 10.1021/jf1006819.