Aim: Most of the time, the failures are conditions that occur during or after appropriately performed fixed prosthodontics treatment procedures. Reasons for failures in fixed prosthodontics can be divided into biological, mechanical and esthetic factors. The present study was conducted to assess biological, mechanical, and esthetic failure factors among fixed partial dentures (FPDs). Materials and methods: A cross-sectional study was conducted among patients who reported to the Department of Prosthodontics, College of Dental Sciences, Davangere, Karnataka, India with complaints about fixed partial denture. A total of 450 fixed partial denture failures in subjects were assessed. The fixed partial denture was examined for the failure factors (biological, mechanical, and esthetic). The selected subjects underwent a clinical examination and set of a questionnaire about the complaint of the fixed partial denture and further detail clinical examination about the failure factor. Results: Out of 450 fixed partial denture failures, 33.3% of it showed the biological failure, 55.1% showed the mechanical failure and 11.5% showed esthetic failure. The most frequent reason for failure was mechanical factors followed by biological and esthetic failure factors. Conclusion: The caries was the most common biological failure factor, the loss of retention was the most common cause of mechanical failure factor and the unacceptable color match was accounted more when compared to other esthetic failure factors. Clinical significance: By knowing the type of failures, we can plan a proper treatment plan so that the abutment will have a long time prognosis.