CODS - Journal of Dentistry

Register      Login

VOLUME 4 , ISSUE 1 ( March, 2012 ) > List of Articles

RESEARCH ARTICLE

Stamps-smart Bombs To Streptococcus Mutans

V.V. Subba Reddy, Sathyajith Naik, R. Krishnakumar, S. Srinivasan

Citation Information : Reddy VS, Naik S, Krishnakumar R, Srinivasan S. Stamps-smart Bombs To Streptococcus Mutans. CODS J Dent 2012; 4 (1):16-18.

DOI: 10.5005/cods-4-1-16

License: CC BY-NC-ND 3.0

Published Online: 01-09-2011

Copyright Statement:  Copyright © 2012; The Author(s).


Abstract

Plaque on the surface of the tooth consists of a bacterial film that produces acids as a by-product of its metabolism. To be specific, certain bacteria within the oral diseases, such as dental caries and periodontal disease, should be considered as consequences of ecologically driven imbalances of oral microbial biofilms. The ecological disruption resulting from antibiotic treatment frequently results in secondary infections or other negative clinical consequences. To address this problem, researchers have recently developed a new class of pathogen-selective molecules, called specifically (or selectively) targeted antimicrobial peptides (STAMPs), and based on the fusion of a species-specific targeting peptide domain with a wide-spectrum antimicrobial peptide domain.


PDF Share
  1. African Journal of Microbiology Research Vol. 4 (II), pp. 1051-1056, 4 June 2010
  2. et al Achieving Probiotic Effects via Modulating Oral Microbial Ecology. ADR 2009 21: 53 originally published online 31 July 2009.
  3. Antimicrobial agents and chemotherapy, Nov. 2006, Vol. 50, No.11 p.3651-3657
  4. Antimicrobial agents and chemotherapy June 2011, Vol. 55, No.6, p. 2679-2687.
  5. 2007, p. 4125-4132 Vol.51, No.11
  6. Novel Synthetic Antimicrobial Peptides against Streptococcus mutans Antimicrobial Agents And Chemotherapy, Apr. 2007, vol. 51, no.4, p.1351-1358
  7. et al Clinical Efficacy of a Specifically Targeted Antimicrobial Peptide Mouth Rinse: Targeted Elimination of Streptococcus mutans and Prevention of Demineralization. Caries Res 2011; 45:415-428.
  8. M. ‘Bob’ ten Cate The Need for Antibacterial Approaches to Improve Caries Control ADR 2009 21: 8 originally published online 27 July 2009
  9. Anne Aamdal Scheie The biofilm concept: consequences For future prophylaxis of oral diseases? Crit Rev Oral Biol Med 15(1):4-12 (2004)
PDF Share
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.