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VOLUME 8 , ISSUE 2 ( 2016 ) > List of Articles


Evaluation of Curcumin 10 mg (Curenext®) as Local Drug Delivery Adjunct in the Treatment of Chronic Periodontitis: A Clinical Trial

Shobha Prakash, Priyanka Shivanand, Kangowkar V Vandana, Kharidhi L Vandana

Keywords : Curcumin, Local drug delivery, Periodontitis, Scaling and root planing

Citation Information : Prakash S, Shivanand P, Vandana KV, Vandana KL. Evaluation of Curcumin 10 mg (Curenext®) as Local Drug Delivery Adjunct in the Treatment of Chronic Periodontitis: A Clinical Trial. CODS J Dent 2016; 8 (2):59-63.

DOI: 10.5005/jp-journals-10063-0014

License: CC BY-NC-ND 3.0

Published Online: 01-03-2018

Copyright Statement:  Copyright © 2016; The Author(s).


Introduction: Plaque control combined with scaling and root planing (SRP) is an effective therapeutic modality for arresting periodontitis. Due to limitation of mechanical therapy such as SRP, local application of drugs has been initiated. Turmeric is not just a remedy, it is the “cure.” Materials and methods: A total of 14 patients diagnosed with chronic periodontitis were included in a split mouth study. Using the split study protocol, upper arch received SRP alone (control group) and lower arch received SRP + intrapocket application of curcumin (CU) 10 mg (Curenext®; experimental group) in selected sites. Plaque index (PI), gingival bleeding index (GBI), gingival index (GI), probing pocket depth (PPD), and clinical attachment level (CAL) were assessed at baseline and 21st, 30th, and 90th day. Results: Intragroup analysis and intergroup analysis showed significant reduction (p < 0.000) in clinical analysis from baseline to 90th day with comparatively better outcomes in the SRP + CU group. No adverse effects were reported. Conclusion: Curcumin has a number of medicinal properties; it is beneficial in many ways and acts as a capable adjunct to SRP in the treatment of periodontal disease.

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  1. Kou Y, Inaba H, Kato T, Tagashira M, Honma D, Kanda T, Ohtake Y, Amano A. Inflammatory responses of gingival epithelial cells stimulated with Porphyromonas gingivalis vesicles are inhibited by hop-associated polyphenols. J Periodontol 2008 Jan;79(1):174-180.
  2. Kornman KS. Mapping the pathogenesis of periodontitis: a new look. J Periodontol 2008 Aug;79(8 Suppl):1560-1568.
  3. Teles R, Teles F, Frias-Lopez J, Paster B, Haffajee A. Lessons learned and unlearned in periodontal microbiology. Periodontol 2000 2013 Jun;62(1):95-162.
  4. Kumar P, Ansari SH, Ali J. Herbal remedies for the treatment of periodontal disease—a patent review. Recent Pat Drug Deliv Formul 2009 Nov;3(3):221-228.
  5. Cugini MA, Haffajee AD, Smith C, Kent RL Jr, Socransky SS. The effect of scaling and root planing on the clinical and microbiological parameters of periodontal diseases: 12-month results. J Clin Periodontol 2000 Jan;27(1):30-36.
  6. Slots J, Ting M. Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis in human periodontal disease: occurrence and treatment. Periodontol 2000 1999 Jun;20(1):82-121.
  7. Paolantonio M, D'Angelo M, Grassi RF, Perinetti G, Piccolomini R, Pizzo G, Annunziata M, D'Archivio D, D'Ercole S, Nardi G, et al. Clinical and microbiologic effects of subgingival controlled-release delivery of chlorhexidine chip in the treatment of periodontitis: a multicenter study. J Periodontol 2008 Feb;79(2):271-282.
  8. Rams TE, Slots J. Local delivery of antimicrobial agents in the periodontal pocket. Periodontol 2000 1996 Feb;10:139-159.
  9. Sambhav J, Rohit R, Ankit Raj U, Garima M. Curcuma longa in the management of inflammatory diseases—a review. Int Ayur Med J 2014 Jan-Feb;2(1):34-40.
  10. Chainani-Wu N. Safety and anti-inflammatory activity of curcumin: a component of turmeric (Curcuma longa). J Altern Complement Med 2003 Feb;9(1):161-168.
  11. Kumar PS, Griffen AL, Moeschberger ML, Leys EJ. Identification of candidate periodontal pathogens and beneficial species by quantitative 16S clonal analysis. J Clin Microbiol 2005 Aug;43(8):3944-3955.
  12. Nagasri M, Madhulatha M, Musalaiah SV, Arvind Kumar P, Murali Krishna CH, Mohan Kumar P. Efficacy of curcumin as an adjunct to scaling and root planning in chronic periodontitis patients: a clinical and microbiological study. J Pharm Bioall Sci 2015 Aug;7(Suppl 2):S554-S558.
  13. Nagpal M, Sood S. Role of curcumin in systemic and oral health: an overview. J Nat Sci Biol Med 2013 Jan;4(1):3-7.
  14. Armitage GC. Development of a classification system for periodontal diseases and conditions. Ann Periodontol 1999 Dec;4(1):1-6.
  15. Löe H. The gingival index, the plaque index and the retention index systems. J Periodontol 1967 Nov;38(6):610-616.
  16. Ainamo J, Bay I. Problems and proposals for recording gingivitis and plaque. Int Dent J 1975 Dec;25(4):229-235.
  17. Syed SA, Svanberg M, Svanberg G. The predominant cultivable dental plaque flora of beagle dogs with gingivitis. J Periodontal Res 1980 Mar;15(2):123-136.
  18. Antcziik-Bouckoms AA, Tulloch JF, Berkey CS. Split-mouth and cross-over designs in dental researh. J Clin Perioäontol 1990 Aug;17(7 Pt 1):446-453.
  19. Riep B, Edesi-Neuss L, Claessen F, Skarabis H, Ehmke B, Flemmig TF, Bernimoulin JP, Göbel UB, Moter A. Are putative periodontal pathogens reliable diagnostic markers? J Clin Microbiol 2009 Jun;47(6):1705-1711.
  20. Anitha V, Rajesh P, Shanmugam M, Priya BM, Prabhu S, Shivakumar V. Comparative evaluation of natural curcumin and synthetic chlorhexidine in the management of chronic periodontitis as a local drug delivery: a clinical and microbiological study. Indian J Dent Res 2015 Jan-Feb;26(1): 53-56.
  21. Paolantonio M, D'Ercole S, Pilloni A, D'Archivio D, Lisanti L, Graziani F, Femminella B, Sammartino G, Perillo L, Tetè S, et al. Clinical, microbiologic, and biochemical effects of subgingival administration of a Xanthan-based chlorhexidine gel in the treatment of periodontitis: a randomized multicenter trial. J Periodontol 2009 Sep;80(9):1479-1492.
  22. Anuradha BR, Bai YD, Sailaja S, Sudhakar J, Priyanka M, Deepika V. Evaluation of anti-inflammatory effects of curcumin gel as an adjunct to scaling and root planing: a clinical study. J Int Oral Health 2015 Jul;7(7):90-93.
  23. Gottumukkala SN, Sudarshan S, Mantena SR. Comparative evaluation of the efficacy of two controlled release devices: chlorhexidine chips and indigenous curcumin based collagen as local drug delivery systems. Contemp Clin Dent 2014 Apr- Jun;5(2):175-181.
  24. McCullagh MC, Raymond D, Kerr MJ, Lusk SL. Prevalensi of hearing loss and accuracy of self-report among factory workers. Noise and Health 2011;13(54):3440-3447.
  25. Dominic CMU, Ezeabasili ACC, Okoro BU. Industrial noise exposure and its effect on blood pressure in adult industry workers. GJEDT 2014;3(3):29-33.
  26. Mortuaire G, Boute O, Hatron PY, Chevalier D. Pilot study of submucosal radiofrequency for epistaxis in hereditary hemorrhagic telangiectasia. Rhinology 2013 Dec;51(4):355-360.
  27. Kumar PS, Matthews CR, Joshi V, de Jager M, Aspiras M. Tobacco smoking affects bacterial acquisition and colonization in oral biofilms. Infect Immun 2011 Nov;79(11): 4730-4738.
  28. Namiot Z, Namiot DB, Kemona A, Gołebiewska M, Bucki R. The effect of cigarette smoking and alcohol consumption on efficacy of Helicobacter pylori eradication. Pol Arch Med Wewn 2000 Sep;104(3):569-574.
  29. Linder JA, Sim I. Antibiotic treatment of acute bronchitis in smokers: a systematic review. J Gen Intern Med 2002 Mar;17(3):230-234.
  30. Lee WK, Ramanathan M Jr, Spannhake EW, Lane AP. The cigarette smoke component acrolein inhibits expression of the innate immune components IL-8 and human betadefensin 2 by sinonasal epithelial cells. Am J Rhinol 2007 Nov-Dec;21(6):658-663.
  31. Kamath PM, Shenoy VS, Mittal N, Sharma NK. Microbiological analysis of paranasal sinuses in chronic sinusitis—a south Indian coastal study. Egypt J Ear Nose Throat All Sci 2013 Nov;14(3):185-189.
  32. Bezerra TF, Pádna FG, Ogawa AI, Gebrim EM, Saldiva PH, Voegels RL. Biofilms in chronic rhinosinusitis with nasal polyps: pilot study. Braz J Otorhinolaryngol 2009 Nov- Dec;75(6):788-793.
  33. Hashemi M, Sadeghi MMM, Omrani MR, Torabi MA. Microbiology and antimicrobial resistance in chronic resistant rhino sinusitis with or without polyp after functional endoscopic sinus surgery. J Res Med Sci 2005;10(3):167-171.
  34. Farahani F, Youse Mashouf R, Hashemian F, Esmaeili R. Antimicrobial resistance patterns of aerobic organisms in patients with chronic rhinosinusitis in Hamadan, Iran. Avicenna J Clin Microb Infec 2014 Aug;1(2):e18961..
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