CODS Journal of Dentistry

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VOLUME 4 , ISSUE 1 ( March, 2012 ) > List of Articles

RESEARCH ARTICLE

Stamps-smart Bombs To Streptococcus Mutans

V.V. Subba Reddy, Sathyajith Naik, R. Krishnakumar, S. Srinivasan

Citation Information : Reddy VS, Naik S, Krishnakumar R, Srinivasan S. Stamps-smart Bombs To Streptococcus Mutans. CODS J Dent 2012; 4 (1):16-18.

DOI: 10.5005/cods-4-1-16

License: CC BY-NC-ND 3.0

Published Online: 00-03-2012

Copyright Statement:  Copyright © 2012; Jaypee Brothers Medical Publishers (P) Ltd.


Abstract

Plaque on the surface of the tooth consists of a bacterial film that produces acids as a by-product of its metabolism. To be specific, certain bacteria within the oral diseases, such as dental caries and periodontal disease, should be considered as consequences of ecologically driven imbalances of oral microbial biofilms. The ecological disruption resulting from antibiotic treatment frequently results in secondary infections or other negative clinical consequences. To address this problem, researchers have recently developed a new class of pathogen-selective molecules, called specifically (or selectively) targeted antimicrobial peptides (STAMPs), and based on the fusion of a species-specific targeting peptide domain with a wide-spectrum antimicrobial peptide domain.


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