CODS Journal of Dentistry

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VOLUME 10 , ISSUE 1 ( January-June, 2018 ) > List of Articles

Original Article

Comparative Evaluation of Antimicrobial Activity of Quercetin against Endodontic Pathogens in Primary Molars

Shagun Sinha, Poornima Parameswarappa, Neena I Eregowda, Mallikarjun Kenchappa, Shilpa Sasalawad

Keywords : Antimicrobial, Chlorhexidine, Endodontic pathogen, Primary molars, Quercetin

Citation Information : Sinha S, Parameswarappa P, Eregowda NI, Kenchappa M, Sasalawad S. Comparative Evaluation of Antimicrobial Activity of Quercetin against Endodontic Pathogens in Primary Molars. CODS J Dent 2018; 10 (1):7-10.

DOI: 10.5005/jp-journals-10063-0042

License: CC BY-NC 4.0

Published Online: 01-06-2018

Copyright Statement:  Copyright © 2018; Jaypee Brothers Medical Publishers (P) Ltd.


Abstract

Background: Endodontic irrigants have an important role in endodontic treatment of primary teeth, owing to their complex anatomy. Quercetin is a natural flavonoid that exhibits significant antimicrobial properties. Objective: To evaluate the antimicrobial activity of 0.2% chlorhexidine, 1% (w/v) quercetin, and 2% (w/v) quercetin against endodontic pathogens in primary molars. Materials and methods: A total of 15 patients of 4–7 years of age with nonvital carious primary molars were selected. A sample from the root canal was obtained using number 15 paper point. Antimicrobial activity was measured using the disk diffusion method, for the following solutions: group I: 0.2% chlorhexidine solution, group II: 1% w/v quercetin solution, and group III: 2% w/v quercetin solution. For each sample, microbial culture was done under the microaerophilic condition. After 24 hours, the maximum inhibition zone was recorded in millimeters. Results: The highest inhibition was shown by group I, 13.13 ± 0.74, followed by group III, 12.00 ± 0.65, and the lowest in group II, i.e., 8.53 ± 0.63. On comparison between groups, statistically significant difference was noted. Conclusion: Maximum antimicrobial activity was shown by 0.2% chlorhexidine, followed by 2% quercetin that showed significant antimicrobial activity against endodontic pathogens in primary molars.


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